To what extent can anything be unnatural if every substance initially came from

To what extent can anything be unnatural if every substance initially came from

To what extent can anything be unnatural if every substance initially came from the earth to begin with? Wouldn't that make all things natural? A colleague of mine reminded me that there are ways to alter different things, but does that make it unnatural if the process by which we have altered a substance is natural? Such alterations exist via heat (natural), combining with another substance (which is also natural) to cause a reaction, and so on... But what makes something (a product of a reaction, perhaps) unnatural? Say reactant A, which is natural, is combined with reactant "B", which is also natural, to create a product which we would call unnatural. How can we call the product of two natural substances unnatural? To make a long question short, what is the difference between natural and unnatural? Keeping in mind that all things are naturally found on earth. What makes something "artificial"?

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